Regenerative Medicine
Introduction
IBGE is the national forefront of advancing techniques in applied and deliverable biomedical field. The regenerative medicine group has established state of the art regenerative medicine treatment options and delivered in the healthcare sector for uplifting the needs and bridging the gaps in modern treatment era.
The chief and most applicable establishments include:
- Stem Cell Therapy
- Human Amniotic Membrane (HAM) Allografts
IBGE with its long-standing contribution in deliverable R&D, equipped with at par modern research facilities and skilled manpower has developed the capacity of stem cells applications for clinical practice. In the year 2020 a collaborative project with world renowned neurosurgeon Prof. Ayub Khan Ommaya (MD, Bethesda, Maryland) was initiated to develop ‘stem-cell solutions’ for incurable ailments of heart and neurons. Beating heart cells and cells of nasal cell lining were grown in culture at the institute's cell culture facility. In addition, two funded projects; dental stem cells and breast cancer stem cells were conducted successfully. Taking advantage of the variety of tangible applications of regenerative medicine, contemporaneous beats in the regenerative medicine aided therapies are heaving the interest of healthcare specialists as well as general public. The fact is bolstering the demand due to ease of application and minimal risks associated in most procedures. Furthermore, IBGE has a leading cGMP and stem cells banking facility to meet national and international requirements associated with the regenerative medicine applications. The institute harbors potential in setting new avenues in translational research.
In regard to the preparation and clinical applications of HAM allografts, IBGE has an outstanding contribution in the biomedical and health care sector. The acceptably wide-ranging applications of HAM products prepared at the institute has gained confidence and reliability in clinical and surgical procedures right from the advent.
Goal
To establish a comprehensive stem cells based solution for regenerative medicine.
To establish amniotic tissue banking and define an array of HAM therapeutic options.
Present Work
Current activities are focused to provide service to consultants and clinicians towards regenerative treatment solutions for permanent ailments like Cerebral Palsy and joint problems. Follow-up investigations have shown significant improvement in clinical parameters of the patients who received stem cells therapy. Patients of early and middle stage knee osteoarthritis have shown remarkably significant alleviation in pain with improved WOMAC score and joint inflammation. Likewise, cognitive and movement disabilities related to CP have shown 30 to 40% improvement after the treatment.
Interestingly in the parallel development, encouraging response was observed when HAM allografts were applied to the burn patient, ophthalmological surgeries, surgical wounds and diabetic foot ulcer(s). The expedited healing of the burns and wound is with the aid of IBGE prepared HAM has opened an all-way new hope for patients, surgeons and clinicians while its clinical trials.
Future Work
- Establish a National Public Stem Cell Bank
- Expand the clinical applications of Stem cells and Cellular Products
- Offer integrated solutions for advanced cellular therapies
- Bring new research avenues in line with national and international aspirations of efficient disease remedial measures and developing new modalities of treatment
- Establish a Regenerative Centre
- Prospective Collaboration with Prof. Julie Daniel and Dr Sajjad Ahmad, Institute of Ophthalmology, UCL, London, UK
- HAM derivatives for more efficacy, accuracy and diverse application choices
